Hextan/Hextan Plus Dosage/Direction for Use

Hextan: Usual starter dose of losartan is 50 mg once daily, with 25 mg recommended for patients with intravascular volume depletion (e.g, patients treated with diuretics) and patients with history of hepatic impairment.
Losartan can be administered once or twice daily with total daily dosage ranging from 25 mg to 100 mg.
If the antihypertensive effect measured at trough using a once-a-day dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response.
Losartan may be administered with other antihypertensive agents.
It may be administered with our without food.
Hextan Plus: Method of Administration: Losartan potassium/Hydrochlorothiazide may be administered with other antihypertensive agents. Losartan potassium/Hydrochlorothiazide tablets should be swallowed with a glass of water Losartan potassium/Hydrochlorothiazide may be administered with or without food.
Hypertension: Losartan potassium and Hydrochlorothiazide is not for use as initial therapy, but in patients whose blood pressure is not adequately controlled by losartan potassium or hydrochlorothiazide alone.
Dose titration with the individual components (losartan and hydrochlorothiazide) is recommended.
When clinically appropriate direct change from monotherapy to the fixed combination may be considered in patients whose blood pressure is not adequately controlled.
The usual maintenance dose of Losartan potassium/Hydrochlorothiazide is one tablet of Losartan potassium/Hydrochlorothiazide 50 mg/12.5 mg (losartan 50 mg/HCTZ 12.5 mg) once daily. For patients who do not respond adequately to Losartan potassium/Hydrochlorothiazide 50 mg/12.5 mg, the dosage may be increased to one tablet of Losartan potassium/Hydrochlorothiazide 100 mg/25 mg (losartan 100 mg/ HCTZ 25 mg) once daily. The maximum dose is one tablet of Losartan potassium/Hydrochlorothiazide 100 mg/25 mg once daily. In general, the antihypertensive effect is attained within three to four weeks after initiation of therapy. Losartan potassium/Hydrochlorothiazide 100/12.5 (losartan 100 mg/ HCTZ 12.5 mg) is available for those patients titrated to 100 mg of Losartan potassium who require additional blood pressure control.
Use in patients with intravascular volume depletion: Volume and /or sodium depletion should be corrected prior to administration of Losartan potassium/Hydrochlorothiazide tablets.
Use in patients with hepatic impairment: Losartan potassium/Hydrochlorothiazide is contraindicated in patients with severe hepatic impairment.
Use in the elderly: Dosage adjustment is not usually necessary for the elderly. Use in children and adolescents (<18 years): There is no experience in children and adolescents. Therefore, Losartan potassium/Hydrochlorothiazide should not be administered to children and adolescents.